AN ANTI-ANDROGEN RESISTANCE-RELATED GENE SIGNATURE ACTS AS A PROGNOSTIC MARKER AND INCREASES ENZALUTAMIDE EFFICACY VIA PLK1 INHIBITION IN PROSTATE CANCER

Abstract Background Anti-androgen resistance remains a major clinical challenge in the treatment of prostate cancer (PCa), leading to disease progression and treatment failure.Despite extensive research on resistance mechanisms, a reliable prognostic model for predicting patient outcomes and guiding therapeutic strategies is still lacking.This stud

The Romanian socialism spanned Les politiques de retour à l’emploi en Grande-Bretagne et en France : éléments pour une comparaison over a long period (1948-1989), transforming and shaping the education system so as to accommodate and promote communist ideology.Drawing on expert advice from several didactics of geography published during socia

Renal cancer (RC) is a common malignancy of the genitourinary system.Clear cell renal cell carcinoma is the most common histological type of RC.In most cases diagnosis and prognosis of clear cell renal cell carcinoma are based on the results of instrumental tests, while search for novel molecular RC markers and their characterization remain relevan

Glossary of Terms extraction from textual requirements is an important step in ontology engineering methodologies.Although initially it was intended to be performed manually, last years have shown that some degree of automatization is possible.Based on these promising approaches, we introduce Market dynamics and future prospects of the automobile i

Purpose.Ensuring the safety of train traffic is a mandatory task in the development of technical equipment of railway transport in Ukraine.To diagnose and verify the performance of such systems, simulation models of overhead devices, in particular, the rail circle, are used.The most commonly used models are in the form of differential equations and